Article
Evaluating immunologic response and clinical deterioration in treatment-naive patients initiating first-line therapies infected with HIV-1 CRF01_AE and subtype B.
Journal of acquired immune deficiency syndromes (1999) - 1 Mar 2013
Oyomopito Rebecca A, Li Patrick C K, Sungkanuparph Somnuek, Phanuphak Praphan, Tee Kok Keng, Sirisanthana Thira, Kantipong Pacharee, Oka Shinichi, Lee Chris K C, Kamarulzaman Adeeba, Choi Jun Yong, Sohn Annette H, Law Matthew, Chen Yi-Ming A
Abstract excerpt
BACKGROUND: HIV-1 group M viruses diverge 25%-35% in envelope, important for viral attachment during infection, and 10%-15% in the pol region, under selection pressure from common antiretrovirals. In Asia, subtypes B and CRF01_AE are common genotypes. Our objectives were to determine whether clinical, immunological, or virological treatment responses differed by genotype in treatment-naive patients initiating...
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