Article
Virologic and immunologic response to cART by HIV-1 subtype in the CASCADE collaboration.
PloS one - 1 Jan 2013
Touloumi Giota, Pantazis Nikos, Chaix Marie-Laure, Bucher Heiner C, Zangerle Robert, Kran Anne-Marte Bakken, Thiebaut Rodolphe, Masquelier Bernard, Kucherer Claudia, Monforte Antonella d'Arminio, Meyer Laurence, Porter Kholoud
Abstract excerpt
BACKGROUND: We aimed to compare rates of virologic response and CD4 changes after combination antiretroviral (cART) initiation in individuals infected with B and specific non-B HIV subtypes. METHODS: Using CASCADE data we analyzed HIV-RNA and CD4 counts for persons infected ≥1996, ≥15 years of age. We used survival and longitudinal modeling to estimate probabilities of virologic response (confirmed HIV-RNA <500...
Topics
- Adult
- Antiretroviral Therapy, Highly Active
- CD4 Lymphocyte Count
- Genotype
- HIV Infections
- HIV-1
- Humans
- Middle Aged
- Treatment Failure
- Treatment Outcome