Immune reconstruction effectiveness of combination antiretroviral therapy for HIV-1 CRF01_AE cluster 1 and 2 infected individuals.

doi:10.1080/22221751.2021.2017755

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Immune reconstruction effectiveness of combination antiretroviral therapy for HIV-1 CRF01_AE cluster 1 and 2 infected individuals.

Emerging microbes & infections - 1 Dec 2022

Li Kang, Chen Huanhuan, Li Jianjun, Feng Yi, Lan Guanghua, Liang Shujia, Liu Meiliang, Rashid Abdur, Xing Hui, Shen Zhiyong, Shao Yiming

Abstract excerpt

There are great disparities of the results in immune reconstruction (IR) of the HIV-1 infected patients during combined antiretroviral therapy (cART), due to both host polymorphisms and viral genetic subtypes. Identifying these factors and elucidating their impact on the IR could help to improve the efficacy. To study the factors influencing the IR, we conducted a 15-year retrospective cohort study of HIV-1...

Topics

Adult
Anti-HIV Agents
Antiretroviral Therapy, Highly Active
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes
Female
Genotype
HIV Envelope Protein gp120
HIV Infections
HIV-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Immune Reconstitution

Male

Middle Aged

Peptide Fragments

Receptors, CXCR4

Retrospective Studies

Viral Tropism

Source

Open in PubMed Open full text

Identifiers

PMID: 34895083
DOI: 10.1080/22221751.2021.2017755
PMCID: PMC8725829

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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