Article
Impact of select immunologic and virologic biomarkers on CD4 cell count decrease in patients with chronic HIV-1 subtype C infection: results from Sinikithemba Cohort, Durban, South Africa.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 15 Sept 2009
Brumme Zabrina, Wang Bingxia, Nair Kriebashne, Brumme Chanson, de Pierres Chantal, Reddy Shabashini, Julg Boris, Moodley Eshia, Thobakgale Christina, Lu Zhigang, van der Stok Mary, Bishop Karen, Mncube Zenele, Chonco Fundisiwe, Yuki Yuko, Frahm Nicole, Brander Christian, Carrington Mary, Freedberg Kenneth, Kiepiela Photini, Goulder Philip, Walker Bruce, Ndung'u Thumbi, Losina Elena
Abstract excerpt
BACKGROUND: The extent to which immunologic and clinical biomarkers influence human immunodeficiency virus type 1 (HIV-1) infection outcomes remains incompletely characterized, particularly for non-B subtypes. On the basis of data supporting in vitro HIV-1 protein-specific CD8 T lymphocyte responses as correlates of immune control in cross-sectional studies, we assessed the relationship of these responses, along...
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