Article
Analysis of JC virus genotype distribution and transcriptional control region rearrangements in human immunodeficiency virus-positive progressive multifocal leukoencephalopathy patients with and without highly active antiretroviral treatment.
Journal of neurovirology - 1 Jan 2003
Ferrante Pasquale, Delbue Serena, Pagani Elisabetta, Mancuso Roberta, Marzocchetti Angela, Borghi Elisa, Maserati Renato, Bestetti Arabella, Cinque Paola
Abstract excerpt
After the introduction of highly active antiretroviral therapy (HAART), the incidence of many acquired immunodeficiency syndrome (AIDS)-related opportunistic infections, but not of progressive multifocal leukoencephalopathy (PML), has been dramatically decreased. However, it has been shown that about 50% of the HAART-treated PML patients had a significantly prolonged (>6 months) survival time, in comparison to...
Topics
- Acquired Immunodeficiency Syndrome
- Antiretroviral Therapy, Highly Active
- Capsid Proteins
- Gene Rearrangement, T-Lymphocyte
- Genotype
- Humans
- JC Virus
- Leukoencephalopathy, Progressive Multifocal
- Transcriptional Activation