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Article

Exploring the genetic architecture of circulating 25-hydroxyvitamin D.

Genetic epidemiology - 1 Jan 2013

Hiraki Linda T, Major Jacqueline M, Chen Constance, Cornelis Marilyn C, Hunter David J, Rimm Eric B, Simon Kelly C, Weinstein Stephanie J, Purdue Mark P, Yu Kai, Albanes Demetrius, Kraft Peter

Abstract excerpt

The primary circulating form of vitamin D is 25-hydroxy vitamin D (25(OH)D), a modifiable trait linked with a growing number of chronic diseases. In addition to environmental determinants of 25(OH)D, including dietary sources and skin ultraviolet B (UVB) exposure, twin- and family-based studies suggest that genetics contribute substantially to vitamin D variability with heritability estimates ranging from 43% to...

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PMID: 23135809
DOI: 10.1002/gepi.21694
PMCID: PMC3524394

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Multi-ethnic analysis shows genetic risk and environmental predictors interact to influence 25(OH)D concentration and optimal vitamin D intakeSemantic proximity Read ↗

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