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Article

Type 2 Diabetes Causally Reduces Circulating Vitamin D Levels: A Multi-Ancestry Mendelian Randomization Study.

Nutrients - 16 Jun 2026

Rout Madhusmita, Blackett Piers, Sanghera Dharambir K

Abstract excerpt

Background: Vitamin D (25(OH)D) deficiency affects over one billion people globally and is associated with type 2 diabetes (T2D) and cardiometabolic diseases. However, causal relationships remain unclear, as vitamin D supplementation has shown limited benefit in reducing the risk of T2D. Genetic studies have identified variants that influence circulating 25(OH)D levels, but whether genetically determined vitamin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42356330
DOI: 10.3390/nu18121944
PMCID: PMC13305945

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