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Article

Genetic Determinants of 25-Hydroxyvitamin D Concentrations and Their Relevance to Public Health.

Nutrients - 20 Oct 2022

Hyppönen Elina, Vimaleswaran Karani S, Zhou Ang

Abstract excerpt

Twin studies suggest a considerable genetic contribution to the variability in 25-hydroxyvitamin D (25(OH)D) concentrations, reporting heritability estimates up to 80% in some studies. While genome-wide association studies (GWAS) suggest notably lower rates (13−16%), they have identified many independent variants that associate with serum 25(OH)D concentrations. These discoveries have provided some novel insight...

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PMID: 36297091
DOI: 10.3390/nu14204408
PMCID: PMC9606877

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