Article
Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration.
Nature communications - 2 Apr 2020
Revez Joana A, Lin Tian, Qiao Zhen, Xue Angli, Holtz Yan, Zhu Zhihong, Zeng Jian, Wang Huanwei, Sidorenko Julia, Kemper Kathryn E, Vinkhuyzen Anna A E, Frater Julanne, Eyles Darryl, Burne Thomas H J, Mitchell Brittany, Martin Nicholas G, Zhu Gu, Visscher Peter M, Yang Jian, Wray Naomi R, McGrath John J
Abstract excerpt
Vitamin D deficiency is a candidate risk factor for a range of adverse health outcomes. In a genome-wide association study of 25 hydroxyvitamin D (25OHD) concentration in 417,580 Europeans we identify 143 independent loci in 112 1-Mb regions, providing insights into the physiology of vitamin D and implicating genes involved in lipid and lipoprotein metabolism, dermal tissue properties, and the sulphonation and...
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