Article
Trees Assembling Mann-Whitney approach for detecting genome-wide joint association among low-marginal-effect loci.
Genetic epidemiology - 1 Jan 2013
Wei Changshuai, Schaid Daniel J, Lu Qing
Abstract excerpt
Common complex diseases are likely influenced by the interplay of hundreds, or even thousands, of genetic variants. Converging evidence shows that genetic variants with low marginal effects (LMEs) play an important role in disease development. Despite their potential significance, discovering LME genetic variants and assessing their joint association on high-dimensional data (e.g., genome-wide data) remain a...
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