Article

Phenotypic Severity of <i>SCN5A</i> Related Bradycardia is Independent of Dominant-Negative and Coupled Gating Effects

2025-08-10

Abstract excerpt

<h4>Background</h4> Pathogenic SCN5A variants are associated with inherited arrhythmias such as long QT syndrome, Brugada syndrome, and sick sinus syndrome (SSS). While Na v 1.5, an α-subunit of the cardiac sodium channel encoded by SCN5A , has been considered to function as a monomer, recent studies reveal that a reduction of sodium current in wild-type (WT) Na v 1.5 can be caused by dimerization with loss-of-fu...

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Literature Corpus work: f8752807-1d4b-5f1a-863d-678efed5a698
DOI: 10.1101/2025.08.06.25332682

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