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Article

The endosomal sorting complex required for transport machinery influences haem uptake and capsule elaboration in Cryptococcus neoformans.

Molecular microbiology - 1 Jun 2015

Hu Guanggan, Caza Mélissa, Cadieux Brigitte, Bakkeren Erik, Do Eunsoo, Jung Won Hee, Kronstad James W

Abstract excerpt

Iron availability is a key determinant of virulence in the pathogenic fungus Cryptococcus neoformans. Previous work revealed that the ESCRT (endosomal sorting complex required for transport) protein Vps23 functions in iron acquisition, capsule formation and virulence. Here, we further characterized the ESCRT machinery to demonstrate that defects in the ESCRT-II and III complexes caused reduced capsule attachment,...

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Identifiers

PMID: 25732100
DOI: 10.1111/mmi.12985
PMCID: PMC4447559

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The endosomal sorting complex required for transport machinery influences haem uptake and capsule elaboration in Cryptococcus neoformans.PMID 25732100Read ↗

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