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Article

Multifunctional Role of Human SPLUNC1 in Pseudomonas aeruginosa Infection

7 Nov 2012

Abstract excerpt

The human short PLUNC1 (SPLUNC1) protein has been identified as a component of the pulmonary antimicrobial response based on its structural similarity to the bactericidal/permeability-increasing (BPI) protein. Using a genetically modified mouse model, we recently verified the antimicrobial activity of SPLUNC1 against Pseudomonas aeruginosa in vivo. To further define the mechanism of epithelial SPLUNC1-mediated...

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PMID: 23132494
DOI: 10.1128/iai.00500-12

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