Article
Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism.
Proceedings of the National Academy of Sciences of the United States of America - 20 Nov 2012
Gorbunova Vera, Hine Christopher, Tian Xiao, Ablaeva Julia, Gudkov Andrei V, Nevo Eviatar, Seluanov Andrei
Abstract excerpt
Blind mole rats Spalax (BMR) are small subterranean rodents common in the Middle East. BMR is distinguished by its adaptations to life underground, remarkable longevity (with a maximum documented lifespan of 21 y), and resistance to cancer. Spontaneous tumors have never been observed in spalacids. To understand the mechanisms responsible for this resistance, we examined the growth of BMR fibroblasts in vitro of...
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