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Knockdown of E2F5 induces cell death via the TP53‑dependent pathway in breast cancer cells carrying wild‑type TP53.

Oncology reports - 1 Nov 2020

Inagaki Yoshinori, Wu Dan, Fujiwara Kyoko, Ishizuka Yoshiaki, Oguni Asako, Tokunaga Tomohiko, Takayama Tadateru, Soma Masayoshi, Fukuda Noboru, Ozaki Toshinori, Masuda Shinobu

Abstract excerpt

E2F transcription factor 5 (E2F5) is a member of the E2F family of transcription factors, which are involved in regulation of various cellular processes, including cellular proliferation, apoptosis, differentiation and DNA damage response. Previously, we reported that E2F5 was aberrantly overexpressed in estrogen receptor (ER)‑negative breast cancer, especially in triple‑negative breast cancer (TNBC). In the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33000282
DOI: 10.3892/or.2020.7761

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