Consensus H3N2 HA immunogens incorporating key antigenic mutations elicit broad-spectrum neutralizing responses.

doi:10.1080/22221751.2026.2731497

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Article

Consensus H3N2 HA immunogens incorporating key antigenic mutations elicit broad-spectrum neutralizing responses.

Emerging microbes & infections - 1 Dec 2026

An Yimeng, Cai Meina, Zhao Chenyan, Zhang Mengyi, Wu Xi, Huang Weijin, Zhou Xu, Wang Youchun

Abstract excerpt

Seasonal influenza A/H3N2 poses a significant public health burden due to its rapid antigenic evolution, necessitating frequent vaccine updates. This study systematically analysed the antigenic evolution of 14 H3N2 vaccine strains (2000-2022) using pseudovirus-based neutralization assays and antigenic cartography. Vaccine strains exhibited cross-neutralization patterns, with higher reactivity among strains from...

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Topics

Influenza A Virus, H3N2 Subtype
Humans
Mutation
Hemagglutinin Glycoproteins, Influenza Virus
Antigens, Viral
Antibodies, Neutralizing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Antibodies, Viral

Influenza Vaccines

Influenza, Human

Antigenic Variation

Cross Reactions

Neutralization Tests

Animals

Source

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Identifiers

PMID: 42703780
DOI: 10.1080/22221751.2026.2731497
PMCID: PMC13573517

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