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Article

Localization and substrate selectivity of sea urchin multidrug (MDR) efflux transporters.

The Journal of biological chemistry - 21 Dec 2012

Gökirmak Tufan, Campanale Joseph P, Shipp Lauren E, Moy Gary W, Tao Houchao, Hamdoun Amro

Abstract excerpt

In this study, we cloned, expressed and functionally characterized Stronglycentrotus purpuratus (Sp) ATP-binding cassette (ABC) transporters. This screen identified three multidrug resistance (MDR) transporters with functional homology to the major types of MDR transporters found in humans. When overexpressed in embryos, the apical transporters Sp-ABCB1a, ABCB4a, and ABCG2a can account for as much as 87% of the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23124201
DOI: 10.1074/jbc.M112.424879
PMCID: PMC3527970

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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