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Article

Aberrant hypomethylation of SALL4 gene in patients with myelodysplastic syndrome.

Leukemia research - 1 Jan 2013

Lin Jiang, Qian Jun, Yao Dong-ming, Qian Wei, Yang Jing, Wang Cui-zhu, Chai Hai-yan, Ma Ji-chun, Deng Zhao-qun, Li Yun, Chen Qin

Abstract excerpt

The abnormalities of SALL4 gene, which encodes a zinc-finger transcription factor and is essential for developmental events, have been found to be involved in tumorigenesis. In this study, we investigated the methylation status of the CpG island of SALL4 promoter region in myelodysplastic syndrome (MDS) using methylation-specific PCR (MSP). Aberrant hypomethylation of SALL4 gene was found in 21.7% (18/83) of the...

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Source

Identifiers

PMID: 23122807
DOI: 10.1016/j.leukres.2012.10.014

Genes

SALL4
IDH1
IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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