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Article

Ets1 and Elk1 transcription factors regulate<i>cancerous inhibitor of protein phosphatase 2A</i>expression in cervical and endometrial carcinoma cells

1 Nov 2012

Abstract excerpt

Cancerous inhibitor of protein phosphatase 2A (CIP2A) has been identified as a proto-oncogene that is overexpressed in various types of human cancers. CIP2A acts by inhibiting protein phosphatase 2A-dependent destabilization of c-Myc, resulting in increased cell proliferation. Here, we have characterized the proximal promoter region of the human CIP2A gene in cervical, endometrial and liver carcinoma cells. The...

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PMID: 23117818
DOI: 10.4161/trns.22518

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