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Article

ETS1 mediates MEK1/2-dependent overexpression of cancerous inhibitor of protein phosphatase 2A (CIP2A) in human cancer cells.

PloS one - 22 Mar 2011

Khanna Anchit, Okkeri Juha, Bilgen Turker, Tiirikka Timo, Vihinen Mauno, Visakorpi Tapio, Westermarck Jukka

Abstract excerpt

EGFR-MEK-ERK signaling pathway has an established role in promoting malignant growth and disease progression in human cancers. Therefore identification of transcriptional targets mediating the oncogenic effects of the EGFR-MEK-ERK pathway would be highly relevant. Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a recently characterized human oncoprotein. CIP2A promotes malignant cell growth and is over...

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Share to Aryl Hydrocarbon Hydroxylases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Promoter Regions, Genetic

Share to Proto-Oncogene Protein c-ets-1

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Source

Open in PubMed Open full text

Identifiers

PMID: 21445343
DOI: 10.1371/journal.pone.0017979
PMCID: PMC3062549

Genes

EGFR
ETS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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