Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Significance of Fibrillin-1, Filamin A, MMP2 and SOX9 in Mitral Valve Pathology

29 Aug 2024

Abstract excerpt

Genetic factors play a significant role in the pathogenesis of mitral valve diseases, including mitral valve prolapse (MVP) and mitral valve regurgitation. Genes like Fibrillin-1 (FBN1), Filamin A (FLNA), matrix metalloproteinase 2 (MMP2), and SRY-box transcription factor 9 (SOX9) are known to influence mitral valve pathology but knowledge of the exact mechanism is far from clear. Data regarding serum parameters,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiac Valve Diseases and Treatments
Share to Peptidase Inhibition and Analysis
Share to Protease and Inhibitor Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39273357
DOI: 10.3390/ijms25179410

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Significance of Fibrillin-1, Filamin A, MMP2 and SOX9 in Mitral Valve PathologyPMID 39273357Read ↗

Genetics of syndromic and non-syndromic mitral valve prolapse.Semantic proximity Read ↗

Emerging pathogenic mechanisms in human myxomatous mitral valve: lessons from past and novel data.Semantic proximity Read ↗

Multimodality imaging and transcriptomics to phenotype mitral valve dystrophy in a unique knock-in Filamin-A rat model.Semantic proximity Read ↗

Inflammation Aggravates Disease Severity in Marfan Syndrome PatientsSemantic proximity Read ↗

Macrophage recruitment is a hallmark of non-syndromic myxomatous mitral valve disease.Semantic proximity Read ↗

Mitral valve prolapse.Semantic proximity Read ↗

Mitral valve disease in Marfan syndrome and related disorders.Semantic proximity Read ↗

Associations of rs3918242 and rs2285053 MMP-9 and MMP-2 polymorphisms with the risk, severity, and short- and long-term complications of degenerative mitral valve diseases: a 4.8-year prospective cohort study.Semantic proximity Read ↗

Genome-wide association study reveals novel genetic loci: a new polygenic risk score for mitral valve prolapseSemantic proximity Read ↗

Cross-Species Multi-Omics Profiling Identifies Conserved Activated Valvular Interstitial Cell Population Driving Myxomatous Mitral Valve DegenerationSemantic proximity Read ↗

Filamin-a-related myxomatous mitral valve dystrophy: genetic, echocardiographic and functional aspects.Semantic proximity Read ↗

Association between fibrillin-1 gene exon 15 and 27 polymorphisms and risk of mitral valve prolapse.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.