Secondary genetic lesions in acute myeloid leukemia with inv(16) or t(16;16): a study of the German-Austrian AML Study Group (AMLSG).

doi:10.1182/blood-2012-05-431486

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Article

Secondary genetic lesions in acute myeloid leukemia with inv(16) or t(16;16): a study of the German-Austrian AML Study Group (AMLSG).

Blood - 3 Jan 2013

Paschka Peter, Du Juan, Schlenk Richard F, Gaidzik Verena I, Bullinger Lars, Corbacioglu Andrea, Späth Daniela, Kayser Sabine, Schlegelberger Brigitte, Krauter Jürgen, Ganser Arnold, Köhne Claus-Henning, Held Gerhard, von Lilienfeld-Toal Marie, Kirchen Heinz, Rummel Mathias, Götze Katharina, Horst Heinz-August, Ringhoffer Mark, Lübbert Michael, Wattad Mohammed, Salih Helmut R, Kündgen Andrea, Döhner Hartmut, Döhner Konstanze

Abstract excerpt

In this study, we evaluated the impact of secondary genetic lesions in acute myeloid leukemia (AML) with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11. We studied 176 patients, all enrolled on prospective treatment trials, for secondary chromosomal aberrations and mutations in N-/KRAS, KIT, FLT3, and JAK2 (V617F) genes. Most frequent chromosomal aberrations were trisomy 22 (18%) and trisomy 8 (16%)....

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Identifiers

PMID: 23115274
DOI: 10.1182/blood-2012-05-431486

Genes

FLT3
KIT
KRAS
CBFB
JAK2
MYH11
NRAS

Variants

Provenance

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