Article
inv(16)/t(16;16) acute myeloid leukemia with non-type A CBFB-MYH11 fusions associate with distinct clinical and genetic features and lack KIT mutations.
Blood - 10 Jan 2013
Schwind Sebastian, Edwards Colin G, Nicolet Deedra, Mrózek Krzysztof, Maharry Kati, Wu Yue-Zhong, Paschka Peter, Eisfeld Ann-Kathrin, Hoellerbauer Pia, Becker Heiko, Metzeler Klaus H, Curfman John, Kohlschmidt Jessica, Prior Thomas W, Kolitz Jonathan E, Blum William, Pettenati Mark J, Dal Cin Paola, Carroll Andrew J, Caligiuri Michael A, Larson Richard A, Volinia Stefano, Marcucci Guido, Bloomfield Clara D
Abstract excerpt
The inv(16)(p13q22)/t(16;16)(p13;q22) in acute myeloid leukemia results in multiple CBFB-MYH11 fusion transcripts, with type A being most frequent. The biologic and prognostic implications of different fusions are unclear. We analyzed CBFB-MYH11 fusion types in 208 inv(16)/t(16;16) patients with de novo disease, and compared clinical and cytogenetic features and the KIT mutation status between type A (n = 182;...
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