Relationship between uptake and elimination of toluene and debrisoquin hydroxylation polymorphism.

doi:10.1038/clpt.1990.47

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Article

Relationship between uptake and elimination of toluene and debrisoquin hydroxylation polymorphism.

Clinical pharmacology and therapeutics - 1 Mar 1990

Löf A, Hansen S H, Näslund P, Steiner E, Wallén M, Hjelm E W

Abstract excerpt

The toxicokinetics of toluene were studied in six healthy subjects. Three of the subjects were phenotyped as rapid hydroxylators of debrisoquin and three subjects were phenotyped as slow hydroxylators of debrisoquin. The subjects were exposed in an exposure chamber to toluene vapor (3.25 mmol/m3)...

Topics

Atmosphere Exposure Chambers
Biotransformation
Cresols
Debrisoquin
Half-Life
Hippurates
Humans
Hydroxylation
Isoquinolines
Lung
Phenotype
Polymorphism, Genetic
Respiration
Toluene

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