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IL28B polymorphisms predict the response to chronic hepatitis C virus infection treatment in a Mexican population.

Annals of hepatology - 1 Jan 2000

Martínez-Gómez Laura E, Chávez-Tapia Norberto C, Burguete-García Ana I, Aguilar-Olivos Nancy, Madrid-Marina Vicente, Román-Bahena Margarita, Orbe-Orihuela Citlalli, Misael Uribe, Méndez-Sánchez Nahum

Abstract excerpt

INTRODUCTION: The treatment of hepatitis C virus (HCV) genotype 1 with ribavirin (RBV) and pegylated-interferon alpha (peg-IFNα) provides a low-level sustained virological response (SVR). Single nucleotide polymorphisms (SNPs) in the interleukin 28B (IL28B) gene have been identified as SVR predictors. Our aim was to establish an association between three IL28B SNPs (rs8099917, rs12979860, and rs8103142) and the...

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PMID: 23109451

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