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Article

GMP-compliant isolation and expansion of bone marrow-derived MSCs in the closed, automated device quantum cell expansion system.

Cell transplantation - 1 Jan 2013

Rojewski Markus T, Fekete Natalie, Baila Stefano, Nguyen Kim, Fürst Daniel, Antwiler Delbert, Dausend Julia, Kreja Ludwika, Ignatius Anita, Sensebé Luc, Schrezenmeier Hubert

Abstract excerpt

The estimated frequency of MSCs in BM is about 0.001-0.01% of total nucleated cells. Most commonly, one applied therapeutic cell dose is about 1-5 million MSCs/kg body weight, necessitating a reliable, fast, and safe expansion system. The limited availability of MSCs demands for an extensive ex vivo amplification step to accumulate sufficient cell numbers. Human platelet lysate (PL) has proven to be a safe and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23107560
DOI: 10.3727/096368912X657990

Genes

MSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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