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Article

Single-platform quality control assay to quantify multipotential stromal cells in bone marrow aspirates prior to bulk manufacture or direct therapeutic use.

Cytotherapy - 1 Apr 2012

Cuthbert Richard, Boxall Sally A, Tan Hiang Boon, Giannoudis Peter V, McGonagle Dennis, Jones Elena

Abstract excerpt

BACKGROUND AIMS: The manufacture of multipotential stromal cell (MSC)-based products is costly; therefore, a rapid evaluation of bone marrow (BM) 'quality' with respect to MSC content is desirable. The aim of this study was to develop a rapid single-platform assay to quantify MSC in BM aspirates. METHODS: Aspirated MSC were enumerated using the CD45(-/low) CD271(bright) phenotype and AccuCheck counting beads and...

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Identifiers

PMID: 22268519
DOI: 10.3109/14653249.2011.651533

Genes

MSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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