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Article

A comprehensive characterisation of large-scale expanded human bone marrow and umbilical cord mesenchymal stem cells

18 Mar 2019

Abstract excerpt

BACKGROUND: The manufacture of mesenchymal stem/stromal cells (MSCs) for clinical use needs to be cost effective, safe and scaled up. Current methods of expansion on tissue culture plastic are labour-intensive and involve several 'open' procedures. We have used the closed Quantum® hollow fibre bioreactor to expand four cultures each of MSCs derived from bone marrow (BM) and, for the first time, umbilical cords...

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PMID: 30885254
DOI: 10.1186/s13287-019-1202-4

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