Article
A comprehensive immunohistochemical and molecular approach to the PI3K/AKT/mTOR (phosphoinositide 3-kinase/v-akt murine thymoma viral oncogene/mammalian target of rapamycin) pathway in bladder urothelial carcinoma.
BJU international - 1 Dec 2012
Korkolopoulou Penelope, Levidou Georgia, Trigka Eleni-Andriana, Prekete Niki, Karlou Maria, Thymara Irene, Sakellariou Stratigoula, Fragkou Paraskevi, Isaiadis Dimitrios, Pavlopoulos Petros, Patsouris Efstratios, Saetta Angelica A
Abstract excerpt
UNLABELLED: What's known on the subject? and What does the study add? A few published studies investigating single or various PI3K/AKT/mTOR signalling components have produced inconsistent results. Moreover, PI3K regulatory subunit p85a and activated p70S6K expression levels have not been previously examined in urothelial carcinoma (UC). The present study addresses simultaneously all key members of PI3K/AKT/mTOR...
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