Article
Mutations in FGFR3 and PIK3CA, singly or combined with RAS and AKT1, are associated with AKT but not with MAPK pathway activation in urothelial bladder cancer.
Human pathology - 1 Oct 2012
Juanpere Nuria, Agell Laia, Lorenzo Marta, de Muga Silvia, López-Vilaró Laura, Murillo Raquel, Mojal Sergi, Serrano Sergio, Lorente José A, Lloreta Josep, Hernández Silvia
Abstract excerpt
Different members of the phosphoinositide 3 kinase--serine threonine protein kinase (PI3K-AKT) pathway are altered in bladder cancer. Fibroblast growth factor receptor 3 (FGFR3) mutations characterize the low-grade tumors, and RAS genes are mutated in approximately 13% of all bladder tumors. Interestingly, a percentage of bladder tumors have alterations in more than 1 PI3K-AKT or rat sarcoma viral oncogene...
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