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Article

Identification of two-component system AfsQ1/Q2 regulon and its cross-regulation with GlnR in Streptomyces coelicolor.

Molecular microbiology - 1 Jan 2013

Wang Rui, Mast Yvonne, Wang Jin, Zhang Weiwen, Zhao Guoping, Wohlleben Wolfgang, Lu Yinhua, Jiang Weihong

Abstract excerpt

The two-component system AfsQ1/Q2 of Streptomyces coelicolor was identified in our previous work as a pleiotropic regulator for antibiotic biosynthesis and morphological differentiation under the condition of a minimal medium supplemented with 75 mM glutamate. In this work, we report the dissection of the mechanism underlying the function of AfsQ1/Q2 on antibiotic production and also the identification of the...

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PMID: 23106203
DOI: 10.1111/mmi.12080

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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