Article
Genome-wide transcriptome analysis reveals that a pleiotropic antibiotic regulator, AfsS, modulates nutritional stress response in Streptomyces coelicolor A3(2).
BMC genomics - 29 Jan 2008
Lian Wei, Jayapal Karthik P, Charaniya Salim, Mehra Sarika, Glod Frank, Kyung Yun-Seung, Sherman David H, Hu Wei-Shou
Abstract excerpt
BACKGROUND: A small "sigma-like" protein, AfsS, pleiotropically regulates antibiotic biosynthesis in Streptomyces coelicolor. Overexpression of afsS in S. coelicolor and certain related species causes antibiotic stimulatory effects in the host organism. Although recent studies have uncovered some of the upstream events activating this gene, the mechanisms through which this signal is relayed downstream leading to...
Topics
- Anthraquinones
- Anti-Bacterial Agents
- Bacterial Proteins
- Chromosomes, Bacterial
- Gene Expression Profiling
- Gene Expression Regulation, Bacterial
- Genes, Bacterial
- Genome, Bacterial
- Glutamate-Ammonia Ligase