Article
Trafficking of ATP-sensitive potassium channels in health and disease.
Biochemical Society transactions - 1 Nov 2007
Sivaprasadarao A, Taneja T K, Mankouri J, Smith A J
Abstract excerpt
K(ATP) channels (ATP-sensitive potassium channels), comprising four subunits each of Kir6.2 (inwardly rectifying potassium channel 6.2) and the SUR1 (sulfonylurea receptor 1), play a central role in glucose-stimulated insulin secretion by the pancreatic beta-cell. Changes in the number of channels at the cell surface are associated with genetic diseases of aberrant insulin secretion, including CHI (congenital...
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