Article
Bayesian refinement of association signals for 14 loci in 3 common diseases.
Nature genetics - 1 Dec 2012
Maller Julian B, McVean Gilean, Byrnes Jake, Vukcevic Damjan, Palin Kimmo, Su Zhan, Howson Joanna M M, Auton Adam, Myers Simon, Morris Andrew, Pirinen Matti, Brown Matthew A, Burton Paul R, Caulfield Mark J, Compston Alastair, Farrall Martin, Hall Alistair S, Hattersley Andrew T, Hill Adrian V S, Mathew Christopher G, Pembrey Marcus, Satsangi Jack, Stratton Michael R, Worthington Jane, Craddock Nick, Hurles Matthew, Ouwehand Willem, Parkes Miles, Rahman Nazneen, Duncanson Audrey, Todd John A, Kwiatkowski Dominic P, Samani Nilesh J, Gough Stephen C L, McCarthy Mark I, Deloukas Panagiotis, Donnelly Peter
Abstract excerpt
To further investigate susceptibility loci identified by genome-wide association studies, we genotyped 5,500 SNPs across 14 associated regions in 8,000 samples from a control group and 3 diseases: type 2 diabetes (T2D), coronary artery disease (CAD) and Graves' disease. We defined, using Bayes theorem, credible sets of SNPs that were 95% likely, based on posterior probability, to contain the causal...
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