Article
Interferon-γ-producing immature myeloid cells confer protection against severe invasive group A Streptococcus infections.
Nature communications - 14 Feb 2012
Matsumura Takayuki, Ato Manabu, Ikebe Tadayoshi, Ohnishi Makoto, Watanabe Haruo, Kobayashi Kazuo
Abstract excerpt
Cytokine-activated neutrophils are known to be essential for protection against group A Streptococcus infections. However, during severe invasive group A Streptococcus infections that are accompanied by neutropenia, it remains unclear which factors are protective against such infections, and which cell population is the source of them. Here we show that mice infected with severe invasive group A Streptococcus...
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