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Article

IL-1 receptor type 1 gene-deficient mice demonstrate an impaired host defense against pneumococcal meningitis.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2003

Zwijnenburg Petra J G, van der Poll Tom, Florquin Sandrine, Roord John J, Van Furth A Marceline

Abstract excerpt

The fatality rate associated with Streptococcus pneumoniae meningitis remains high despite adequate antibiotic treatment. IL-1 is an important proinflammatory cytokine, which is up-regulated in brain tissue after the induction of meningitis. To determine the role of IL-1 in pneumococcal meningitis we induced meningitis by intranasal inoculation with 8 x 10(4) CFU of S. pneumoniae and 180 U of hyaluronidase in...

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Source

Identifiers

PMID: 12707352
DOI: 10.4049/jimmunol.170.9.4724

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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