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The Aurora Kinase C c.144delC mutation causes meiosis I arrest in men and is frequent in the North African population.

Human molecular genetics - 1 Apr 2009

Dieterich Klaus, Zouari Raoudha, Harbuz Radu, Vialard François, Martinez Delphine, Bellayou Hanane, Prisant Nadia, Zoghmar Abdelali, Guichaoua Marie Roberte, Koscinski Isabelle, Kharouf Mahmoud, Noruzinia Mehrdad, Nadifi Sellama, Sefiani Abdelaziz, Lornage Jacqueline, Zahi Mohamed, Viville Stéphane, Sèle Bernard, Jouk Pierre-Simon, Jacob Marie-Christine, Escalier Denise, Nikas Yorgos, Hennebicq Sylviane, Lunardi Joël, Ray Pierre F

Abstract excerpt

Infertility concerns a minimum of 70 million couples worldwide. An important proportion of cases is believed to have a genetic component, yet few causal genes have been identified so far. In a previous study, we demonstrated that a homozygous mutation (c.144delC) in the Aurora Kinase C (AURKC) ge...

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Identifiers

PMID: 19147683
DOI: 10.1093/hmg/ddp029

Genes

AURKC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19147683-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Aurora Kinase C c.144delC mutation causes meiosis I arrest in men and is frequent in the North African population.PMID 19147683Read ↗

[Function of aurora kinase C (AURKC) in human reproduction].Semantic proximity Read ↗

A new AURKC mutation causing macrozoospermia: implications for human spermatogenesis and clinical diagnosis.Semantic proximity Read ↗

Prevalence of the Aurora kinase C c.144delC mutation in infertile Moroccan men.Semantic proximity Read ↗

Identification of a new recurrent aurora kinase C mutation in both European and African men with macrozoospermia.Semantic proximity Read ↗

[Confirmation of the high prevalence in Morocco of the homozygous mutation c.144delC in the aurora kinase C gene (AURKC) in the teratozoospermia with large-headed spermatozoa].Semantic proximity Read ↗

Two frequent loss-of-function mutations in Aurora Kinase C gene in Algerian infertile men with macrozoospermia.Semantic proximity Read ↗

Mutations of the aurora kinase C gene causing macrozoospermia are the most frequent genetic cause of male infertility in Algerian men.Semantic proximity Read ↗

Compound heterozygosity for novel AURKC mutations in an infertile man with macrozoospermia.Semantic proximity Read ↗

Characterization of macrozoospermia-associated AURKC mutations in a mammalian meiotic system.Semantic proximity Read ↗

Successful intracytoplasmic sperm injection in a macrozoospermia case with novel compound heterozygous aurora kinase C (AURKC) mutations.Semantic proximity Read ↗

Diagnostic genetic screening for assisted reproductive technologies patients with macrozoospermiaSemantic proximity Read ↗

Identification and characterization of Aurora kinase B and C variants associated with maternal aneuploidy.Semantic proximity Read ↗

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