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Article

Mutations of the SYCP3 gene in women with recurrent pregnancy loss.

American journal of human genetics - 1 Jan 2009

Bolor Hasbaira, Mori Terumi, Nishiyama Sachie, Ito Yoshimasa, Hosoba Eriko, Inagaki Hidehito, Kogo Hiroshi, Ohye Tamae, Tsutsumi Makiko, Kato Takema, Tong Maoqing, Nishizawa Haruki, Pryor-Koishi Kanako, Kitaoka Eri, Sawada Tomio, Nishiyama Yukio, Udagawa Yasuhiro, Kurahashi Hiroki

Abstract excerpt

Aneuploidy, a chromosomal numerical abnormality in the conceptus or fetus, occurs in at least 5% of all pregnancies and is the leading cause of early pregnancy loss in humans. Accumulating evidence now suggests that the correct segregation of chromosomes is affected by events occurring in prophase during meiosis I. These events include homologous chromosome pairing, sister-chromatid cohesion, and meiotic...

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Source

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Identifiers

PMID: 19110213
DOI: 10.1016/j.ajhg.2008.12.002
PMCID: PMC2668043

Genes

SYCP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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Mutations of the SYCP3 gene in women with recurrent pregnancy loss.PMID 19110213Read ↗

The T657C polymorphism on the SYCP3 gene is associated with recurrent pregnancy loss.Semantic proximity Read ↗

Analysis of SYCP3 encoding synaptonemal complex protein 3 in human aneuploidies.Semantic proximity Read ↗

Azoospermia in patients heterozygous for a mutation in SYCP3.Semantic proximity Read ↗

A rare synaptonemal complex protein 3 gene variant in unexplained female infertility.Semantic proximity Read ↗

Genetics of recurrent pregnancy loss: a reviewSemantic proximity Read ↗

Mutations in Genes Coding for Synaptonemal Complex Proteins and Their Impact on Human Fertility.Semantic proximity Read ↗

Variant in the synaptonemal complex protein SYCE2 associates with pregnancy loss through effect on recombinationSemantic proximity Read ↗

Investigation of mutations in the synaptonemal complex protein 3 (SYCP3) gene among azoospermic infertile male patients in the Turkish population.Semantic proximity Read ↗

A homozygous NOP14 variant is likely to cause recurrent pregnancy loss.Semantic proximity Read ↗

Biallelic variant in cyclin B3 is associated with failure of maternal meiosis II and recurrent digynic triploidySemantic proximity Read ↗

Mutation screening of AURKB and SYCP3 in patients with reproductive problems.Semantic proximity Read ↗

SYCP2 Translocation-Mediated Dysregulation and Frameshift Variants Cause Human Male Infertility.Semantic proximity Read ↗

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