Article
A fibrillin-1-fragment containing the elastin-binding-protein GxxPG consensus sequence upregulates matrix metalloproteinase-1: biochemical and computational analysis.
Journal of molecular and cellular cardiology - 1 Feb 2006
Booms Patrick, Ney Andreas, Barthel Frank, Moroy Gautier, Counsell Damian, Gille Christoph, Guo Gao, Pregla Reinhard, Mundlos Stefan, Alix Alain J P, Robinson Peter N
Abstract excerpt
Mutations in the gene for fibrillin-1 cause Marfan syndrome (MFS), a common hereditary disorder of connective tissue. Recent findings suggest that proteolysis, increased matrix metalloproteinase activity, and fragmentation of fibrillin-rich microfibrils in tissues of persons with MFS contribute to the complex pathogenesis of this disorder. In this study we show that a fibrillin-1 fragment containing a EGFEPG...
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