Article
Human Asunder promotes dynein recruitment and centrosomal tethering to the nucleus at mitotic entry.
Molecular biology of the cell - 1 Dec 2012
Jodoin Jeanne N, Shboul Mohammad, Sitaram Poojitha, Zein-Sabatto Hala, Reversade Bruno, Lee Ethan, Lee Laura A
Abstract excerpt
Recruitment of dynein motors to the nuclear surface is an essential step for nucleus-centrosome coupling in prophase. In cultured human cells, this dynein pool is anchored to nuclear pore complexes through RanBP2-Bicaudal D2 (BICD2) and Nup133- centromere protein F (CENP-F) networks. We previously reported that the asunder (asun) gene is required in Drosophila spermatocytes for perinuclear dynein localization and...
Topics
- 1-Alkyl-2-acetylglycerophosphocholine Esterase
- Animals
- Carrier Proteins
- Cell Cycle Proteins
- Cell Line, Tumor
- Cell Nucleus
- Centrosome
- Chromosomal Proteins, Non-Histone
- Drosophila melanogaster
- Dyneins
- Female
- G2 Phase
- Genetic Complementation Test