Article
Asunder is a critical regulator of dynein-dynactin localization during Drosophila spermatogenesis.
Molecular biology of the cell - 1 Jun 2009
Anderson Michael A, Jodoin Jeanne N, Lee Ethan, Hales Karen G, Hays Thomas S, Lee Laura A
Abstract excerpt
Spermatogenesis uses mitotic and meiotic cell cycles coordinated with growth and differentiation programs to generate functional sperm. Our analysis of a Drosophila mutant has revealed that asunder (asun), which encodes a conserved protein, is an essential regulator of spermatogenesis. asun spermatocytes arrest during prophase of meiosis I. Strikingly, arrested spermatocytes contain free centrosomes that fail to...
Topics
- Animals
- Animals, Genetically Modified
- Cell Cycle Proteins
- Cell Nucleus
- Chromosome Segregation
- Drosophila Proteins
- Drosophila melanogaster
- Dynactin Complex
- Dyneins
- Fertility
- Green Fluorescent Proteins
- HeLa Cells
- Humans