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Article

DNA repair: the culprit for tumor-initiating cell survival?

Cancer metastasis reviews - 1 Jun 2011

Mathews Lesley A, Cabarcas Stephanie M, Farrar William L

Abstract excerpt

The existence of "tumor-initiating cells" (TICs) has been a topic of heated debate for the last few years within the field of cancer biology. Their continuous characterization in a variety of solid tumors has led to an abundance of evidence supporting their existence. TICs are believed to be responsible for resistance against conventional treatment regimes of chemotherapy and radiation, ultimately leading to...

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Identifiers

PMID: 21340664
DOI: 10.1007/s10555-011-9277-0
PMCID: PMC3078299

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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