Improved eIF4E binding peptides by phage display guided design: plasticity of interacting surfaces yield collective effects.

Abstract excerpt

Eukaryotic initiation factor (eIF)4E is over-expressed in many types of cancer such as breast, head and neck, and lung. A consequence of increased levels of eIF4E is the preferential translation of pro-tumorigenic proteins (e.g. c-Myc and vascular endothelial growth factor) and as a result is regarded as a potential therapeutic target. In this work a novel phage display peptide has been isolated against eIF4E....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Amino Acids
• Share to Drug Design
• Share to Eukaryotic Initiation Factor-4E