Article
Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX.
The Journal of biological chemistry - 15 Jan 2010
Phan Jason, Li Zhenyu, Kasprzak Agnieszka, Li Baozong, Sebti Said, Guida Wayne, Schönbrunn Ernst, Chen Jiandong
Abstract excerpt
MDM2 and MDMX function as key regulators of p53 by binding to its N terminus, inhibiting its transcriptional activity, and promoting degradation. MDM2 and MDMX overexpression or hyperactivation directly contributes to the loss of p53 function during the development of nearly 50% of human cancers. Recent studies showed that disrupting p53-MDM2 and p53-MDMX interactions can lead to robust activation of p53 but also...
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