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Article

Identification of FAM111A as an SV40 Host Range Restriction and Adenovirus Helper Factor

18 Oct 2012

Abstract excerpt

The small genome of polyomaviruses encodes a limited number of proteins that are highly dependent on interactions with host cell proteins for efficient viral replication. The SV40 large T antigen (LT) contains several discrete functional domains including the LXCXE or RB-binding motif, the DNA binding and helicase domains that contribute to the viral life cycle. In addition, the LT C-terminal region contains the...

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PMID: 23093934
DOI: 10.1371/journal.ppat.1002949

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