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Article

Exploration of gene-environment interactions, maternal effects and parent of origin effects in the etiology of hypospadias.

The Journal of urology - 1 Dec 2012

van der Zanden Loes F M, Galesloot Tessel E, Feitz Wout F J, Brouwers Marijn M, Shi Min, Knoers Nine V A M, Franke Barbara, Roeleveld Nel, van Rooij Iris A L M

Abstract excerpt

PURPOSE: Hypospadias is a common congenital malformation of the male external genitalia. Association studies for single nucleotide polymorphisms in genes encoding steroid 5alpha-reductase, estrogen receptors 1 and 2, and activating transcription factor 3 have been equivocal. We examined whether nonreplication of findings for 4 single nucleotide polymorphisms in these genes could be due to interaction with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23088992
DOI: 10.1016/j.juro.2012.08.033
PMCID: PMC3602843

Genes

ATF3
ESR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Exploration of gene-environment interactions, maternal effects and parent of origin effects in the etiology of hypospadias.PMID 23088992Read ↗

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