Article
Inhibition of melanocortin-4 receptor dimerization by substitutions in intracellular loop 2.
Journal of molecular endocrinology - 1 Jan 2013
Piechowski Carolin L, Rediger Anne, Lagemann Christina, Mühlhaus Jessica, Müller Anne, Pratzka Juliane, Tarnow Patrick, Grüters Annette, Krude Heiko, Kleinau Gunnar, Biebermann Heike
Abstract excerpt
Obesity is one of the most challenging global health problems. One key player in energy homeostasis is the melanocortin-4 receptor (MC4R), which is a family A G-protein-coupled receptor (GPCR). It has recently been shown that MC4R has the capacity to form homo- or heterodimers. Dimerization of GPCRs is of great importance for signaling regulation, with major pharmacological implications. Unfortunately, not enough...
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