Article
G9a mediates Sharp-1-dependent inhibition of skeletal muscle differentiation.
Molecular biology of the cell - 1 Dec 2012
Ling Belinda Mei Tze, Gopinadhan Suma, Kok Wai Kay, Shankar Shilpa Rani, Gopal Pooja, Bharathy Narendra, Wang Yaju, Taneja Reshma
Abstract excerpt
Sharp-1, a basic helix-loop-helix transcription factor, is a potent repressor of skeletal muscle differentiation and is dysregulated in muscle pathologies. However, the mechanisms by which it inhibits myogenesis are not fully understood. Here we show that G9a, a lysine methyltransferase, is involved in Sharp-1-mediated inhibition of muscle differentiation. We demonstrate that G9a directly interacts with Sharp-1...
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