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Abnormalities in the Climbing Fiber-Purkinje Cell Circuitry Contribute to Neuronal Dysfunction in<i>ATXN1</i>[<i>82Q</i>] Mice

7 Sept 2011

Abstract excerpt

One fundamental unanswered question in the field of polyglutamine diseases concerns the pathophysiology of neuronal dysfunction. Is there dysfunction in a specific neuronal population or circuit initially that contributes the onset of behavioral abnormalities? This study used a systems-level approach to investigate the functional integrity of the excitatory cerebellar cortical circuitry in vivo from several...

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PMID: 21900557
DOI: 10.1523/jneurosci.2579-11.2011

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