Article
The novel tumor suppressor NOL7 post-transcriptionally regulates thrombospondin-1 expression.
Oncogene - 12 Sept 2013
Doçi C L, Zhou G, Lingen M W
Abstract excerpt
Thrombospondin-1 (TSP-1) is an endogenous inhibitor of angiogenesis whose expression suppresses tumor growth in vivo. Like many angiogenesis-related genes, TSP-1 expression is tightly controlled by various mechanisms, but there is little data regarding the contribution of post-transcriptional processing to this regulation. NOL7 is a novel tumor suppressor that induces an antiangiogenic phenotype and suppresses...
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